The influence of regional language and culture is significant in Fazali's Novel, Khon-e-Jigar Hony Tak being the greatest genre of Urdu language has a greater capacity of linguistic content and cultent commentary than other genres of Urdu language. There, we can maintain that Pakistani Urdu novel has the impact of regional languages and culture. Due to its cultural and civilizational aspects, Urdu language has an ability of expansion. The living and progressive languages have the capacity to absorb new words. This process of comprehension and acquisition synchronize the language with the new times. Therefore, the adoption of modern, terms of science and arts helps expansion. Evolution has been innate in Urdu since its inception with the espousal of words of regional languages, people of different areas can come closer. As human beings, divided into different tribes and families, are in contact with each other; likewise, the languages, being apart, have deep concern amongst them.